Ganciclovir Mechanism Of Action
Ganciclovir Mechanism Of Action. It is first phosphorylated to a deoxyguanosine triphosphate (dgtp) analogue. Web ganciclovir triphosphate serves as a competitive inhibitor of herpes viral dna polymerase and inhibits the incorporation of guanosine triphosphate into viral dna.
The agent also has activity against other herpesviruses (table 1). Web ganciclovir is a nucleoside analogue with antiviral activity in vitro against members of the herpes group and some other dna viruses. Web ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate incorporation into dna, and preferentially inhibits viral more than host cellular dna.
After Undergoing Cellular Phosphorylation To Its Diphosphate Form, It Competitively Inhibits.
Web mechanism of action valganciclovir is a prodrug of ganciclovir that exists as a mixture of two diastereomers. Ganciclovir is an antiviral drug with activity against cmv [see microbiology]. Web ganciclovir was the first agent identified to have significant activity against cmv [1, 2].
Web Mechanism Of Action.
Web ganciclovir triphosphate serves as a competitive inhibitor of herpes viral dna polymerase and inhibits the incorporation of guanosine triphosphate into viral dna. The agent also has activity against other herpesviruses (table 1). Web ganciclovir can also increase the concentration of didanosine.
After Administration, These Diastereomers Are Rapidly Converted To.
Web mechanism of action cidofovir is a monophosphate nucleotide analog. It is first phosphorylated to a deoxyguanosine triphosphate (dgtp) analogue. Web ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate incorporation into dna, and preferentially inhibits viral more than host cellular dna.
Web Ganciclovir Is A Nucleoside Analogue With Antiviral Activity In Vitro Against Members Of The Herpes Group And Some Other Dna Viruses.
Web mechanism of action among the large group of nucleosides with antiviral activity against herpes simplex viruses, ganciclovir is unique in having high potency against hcmv.
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